Contents [ printable ]

JFW - John Frederick Wilkinson Papers

Mandelic Acid (1935-1936)

Reference GB 133 JFW/2/5/1/14
Physical Description 1 file

Scope and Content

List of patients being treated with mandelic acid and NaH2PO4, or monosodium phosphate, showing the effect on the pH of their urine. There is also correspondence from F.L. Pyman of the Boots Pure Drug Co. in which he encloses additional correspondence received by him from Prof C.R. Harington of University College London and Dr M.L. Rosenheim also of University College Hospital in which they express their opinions on Neoket, the new preparation of mandelic acid recently marketed by Boots. Pyman also supplies Wilkinson with samples of syrup of sodium mandelate and a compound of mandelic acid granules.

Included in the file are copies of D.M. Lyon & D.M. Dunlop, 'Mandelic Acid in the Treatment of Urinary Infections', British Medical Journal, 1935, 2(3909), pp.1096-1097 and also an extract from St Bartholomew's Hospital Reports by Lawrence P. Garrod entitled 'A Study of Urinary Antiseptics', 1935.


N.V. Organon (1936-1946)

Reference GB 133 JFW/2/5/1/15
Physical Description 1 file

Scope and Content

Correspondence received by Wilkinson from N.V. Organon relating to supplies of Pernaemon, a preparation of liver extract produced by them, and details on the preparation of different batches of it.

There is an additional letter from N.V. Organon relating to kawakawa [New Zeland shrub], and a few handwritten notes on the subject.


Formijne (1945)

Reference GB 133 JFW/2/5/1/16
Physical Description 1 file

Scope and Content

Two letters from Alison MacBeth of Organon Laboratories enclosing Scandinavian data from Dr Lens and also data from Dr Formijne, Amsterdam relating to their trials of Pernaemon.


Xanthopterin (1945)

Reference GB 133 JFW/2/5/1/17
Physical Description 1 file

Scope and Content

Correspondence with Organon Laboratories concerning the possibilities that xanthopterin may contain anti-pernicious anaemia factor. There is further related discussion surrounding folic acid, corticotrophin, batyl alcohol, possible counteractive effects of xanthopterin on the effect of thiouracil on the leucocytes, the pituitary and anaemia, the conjugation of proteins and hormones, and observations on pterine pigments. Additionally there is a report on an interview with Dr A. Vannotti and Dr M. Mamie, both of Lausanne University whose present works concern the active anti-(hyperchromic) anaemia substances.

The file also contains the first page of medical notes of a man admitted to the Manchester Royal Infirmary with a septic arm and suffering from pernicious anaemia. The reverse of the page also contains a genealogical tree of the patient showing the family ties to pernicious anaemia. Finally there is also a report on titrations carried out on a by-product of the nitrogen mustard T773.

Conditions Governing Access

This file contains personal medical information relating to several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Misc Research Papers (1933-1941)

Reference GB 133 JFW/2/5/1/18
Physical Description 1 file

Scope and Content

Miscellaneous papers relating to Wilkinson's research on pernicious anaemia and some specific patients as well as a few items of correspondence. Included is a copy of a letter written by one female patient to her husband complaining of the treatment. There are also papers on the storage of blood and a letter dated 1941 from C. Bastin, the Minister Plenipotentiary and Director-General at the Belgian Government Central Bureau for Refugees thanking Wilkinson for his treatment of a young Belgian refugee who unfortunately died. There is also a letter from L. Foulds dated 1940 discussing the effect of war and him going into the Emergency Public Health Laboratory Service in Cambridge and a letter from the Department of Bacteriology and Preventive Medicine at the University of Manchester dated 1937 discussing nematodes from the liver of elephant.

Conditions Governing Access

This file contains personal medical information of several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Boots Research Conferences (Mar 1944-Apr 1947)

Reference GB 133 JFW/2/5/1/19
Physical Description 1 file Some water damage

Scope and Content

Reports of the 113th-127th research conferences hosted by the Boots Pure Drug Co. at Stamford Street, London in addition to reports of the Research Conference (Chemical Section). In these reports the members, including Wilkinson, give overviews of their current research and its progress and the interactions between the different researchers is also recorded. There are also a number of items of correspondence from J.P.M. Coppock mostly just accompanying the reports but also sending other relevant research updates and information regarding potential staff.


MRC Addison's Disease (1934-1938)

Reference GB 133 JFW/2/5/2
Physical Description 4 items

Scope and Content

Wilkinson began his research into Addison's Disease in 1934 at the request of the Therapeutic Trials Committee of the Medical Research Council. The research focused specifically on the value of extracts of suprarenal cortex in the treatment of the disease and similar work was carried out simultaneously by Professor T.R. Elliott of the University College Hospital, London, Dr Robert Hutchison and Dr S. Levy Simpson of the London Hospital, and Professor D. Murray Lyon of the Royal Infirmary, Edinburgh.

See JFW/5/2/3 for correspondence between Wilkinson and the Therapeutic Trials Committee of the MRC regarding the details of the trial.

Where the original files survived at the time of cataloguing the titles given on the file itself have been retained. These files have now been replaced for conservation purposes.


The Value of Extracts of Suprarenal Cortex in the Treatment of Addison's D. Report to T.T.C., M.R.C. (1934-1936)

Reference GB 133 JFW/2/5/2/1
Physical Description 1 file

Scope and Content

This file contains the medical notes of five individual patients admitted to the Manchester Royal Infirmary and diagnosed with Addison's disease. These files give their name, age, address, and dates of admission and discharge. In addition a description of the history of the present complaint and condition on admission, charts recording their condition throughout their stay and the administration of treatment, and reports and results of tests carried out by the clinical laboratory.

As well as the patient notes there are a number of typed patient reports produced by Wilkinson in the course of his investigations, an autopsy report, and tables showing the vital statistics of unnamed patients in relation to the administration of Eucortone treatment. Finally there is a leaflet entitled '"Eucortone" Active Extract of Suprarenal Cortex for the Treatment of Addison's Disease' published by Allen & Hanburys Ltd. Originally numbered "59".

Conditions Governing Access

This file contains personal medical information relating to several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Addison's Disease (1934-1936)

Reference GB 133 JFW/2/5/2/2
Physical Description 1 file

Scope and Content

Typescript reports on patients with Addison's disease seen by Wilkinson as part of the research on behalf of the Therapeutic Trials Committee. Many of these reports are heavily annotated and have copies of the patient's charts attached, which record their condition during their hospital stay in addition to the administration of either Eucortone (Allen & Hanburys Ltd.) or Cortin (Organon Laboratories). The reports give details such as history of the condition, previous medical condition, family history, examination, test results, and where applicable an autopsy report.

Conditions Governing Access

This file contains personal medical information of several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Clinical and Therapeutic Aspects of Addison's Disease. Mis. notes on Add.Dis. (1936)

Reference GB 133 JFW/2/5/2/3
Physical Description 1 file

Scope and Content

Typescript report by Wilkinson entitled 'Some Clinical and Therapeutic Aspects of Addison's Disease' and dated February 1936 in which he discusses the aetiology, pathology, symptoms, and treatment of the disease. In addition there is a further report of the same date to the Therapeutic Trials Committee on the use of suprarenal cortical extracts in Addison's disease in which he gives an overview of some of the 18 cases seen by him so far since the beginning of 1934 as part of the investigations and treated with either Eucortone (Allen & Hanburys Ltd.) or Cortin (Organon Laboratories), or both.

An account of a discussion opened by Wilkinson into the contents of the above report suggests that it may have been discussed in a meeting of the Therapeutic Trials Committee at some point. The file also contains a post mortem report of one of Wilkinson's patients. Originally numbered "9".

Conditions Governing Access

This file contains personal medical information of several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Addison's Disease-Final Report (1937-1938)

Reference GB 133 JFW/2/5/2/4
Physical Description 1 file

Scope and Content

Copy of Wilkinson's final report sent to the Medical Research Council on 16 June 1937. This was later published as Wilkinson, J.F., 'The Value of Extracts of Suprarenal Cortex in the Treatment of Addison's Disease', The Lancet, Vol. 230 Issue 5941 (July 1937), pp.61-70.

There is a second draft manuscript that was sent to the Royal Society of Medicine in December 1938 in which Wilkinson discusses the findings of his investigations and the results of Cortin therapy.


Ministry of Food (1939-1944)

Reference GB 133 JFW/2/5/3
Physical Description 3 items

Scope and Content

Research relating to health and nutrition that Wilkinson undertook during the World War (1939-1945) on behalf of the Ministry of Food.


Vitamins-Nurses' Diet. Blackcurrant Juice-details of (1941-1942)

Reference GB 133 JFW/2/5/3/1
Physical Description 1 file

Scope and Content

Correspondence regarding investigations into levels of vitamins A and C in schoolchildren in Glossop and the subsequent effects of any deficiencies. The investigations were instigated by the Ministry of Health and approximately 400 children were involved in the trials between October 1941 and July 1942. Much of the investigations were carried out by Wilkinson, his colleague Dr G. Kohn, and the Medical Officer of Health for the Borough of Glossop, Dr E. H. Marcus Milligan. Much of the file consists of correspondence between these three men discussing the arrangements to be made to carry out the investigations as well as tests carried out regarding the vitamin content of certain foodstuffs. There is also correspondence with Dr Burns, Medical Officer of Health for Salford, regarding the latter matter.

Specific investigations were carried out into the possible causal link between nutritional deficiency and gingivitis leading to additional correspondence with Patricia Fitzsimmonds of Glaxo Laboratories Ltd. from whom they sought supplies of Nicorbin, Caldeferrum, and ascorbic acid.

There is additional correspondence regarding blackcurrant juice with W. K. Slater of Dartington Hall Ltd., Mr Cable, the General Superintendent and Secretary at the Manchester Royal Infirmary (MRI), and F. D. Armstorng of H. W. Carter & Co. Ltd. Finally there is a report on vitamin deficiency in the nursing staff at the MRI.

The investigations into the health of the Glossop schoolchildren resulted in the following publication: Kohn, G., Milligan, E.H.M., & Wilkinson, J.F., 'Levels of Vitamin A and C Nutrition in Glossop School-Children and Effect of Deficiencies on Their Physical Condition', British Medical Journal, Vol. 2 Issue 4319 (Oct 1943), p.477.


Oats etc. Food. Flour. Mrs Goodman. Dr Picton. (1939-1944)

Reference GB 133 JFW/2/5/3/2
Physical Description 1 file

Scope and Content

Two Memos of the Cheshire Panel Committee's position for presentation to Lord Woolton in November 1942 and November 1943, which despite the two different dates are identical in content. Within they address technical objections to whole meal, advantage of freshly ground flour, wheat germ, effect upon life of including offals in bread, and extract from the article 'The Effect of Food Restriction During War on Mortality in Copenhagen' by M. Hindhede, Controller of Food in Denmark in European War. The Committee consisted of John Kerr, John Wilkinson, George Wood, and Lionel James Picton. These memos are accompanied by a letter from Picton to Lord Woolton emphasising their support for wholemeal flour.

There are a number of items of correspondence received from Mrs Peggy Goodman of Corwen, Wales in which she discusses the nutritional value of specific types of oatmeal and in particular Sowens, or the Welsh version known as Llymru, with recipes for making them. She also sends samples of oat offal or Llymru meal or Eisen Toppings and a copy of her article 'The "Oslo Breakfast": A Village Experiment in Food Reform' originally published in The Vegetarian News in November 1939. There is also an explanation of the Oslo Breakfast reprinted from the June 1940 issue of Housecraft.

There are two handwritten letters from Picton to Wilkinson discussing the grains further as well as referring two named patients to him; a notification of 1 January 1940 from R & A Hannay Ltd., Millers and Grain Merchants regarding an upcoming wireless talk on oatmeal by Sir John Boyd Orr; and results of analysis of three samples carried out by Melling & Ardern, analytical and consulting chemists.


Dehydration (1942-1944)

Reference GB 133 JFW/2/5/3/3
Physical Description 1 file

Scope and Content

Notes and correspondence relating to the dehydration of vegetables and their subsequent nutritional value, including preliminary drawings for a dehydration plant and quotes for specific parts. Amongst this is data on the de-hydration of potatoes, information extracted from the Meat Traders' Journal on the nutritional value of dehydrated meat, English patent no. 463,872 relating to the preparation of fish, report on the dehydration of vegetables by The Canners (War Time) Association, and correspondence from Imperial Chemical Industries (ICI) Ltd. discussing methods of dehydration and the possible disadvantages.

The file also contains a report on the determination of ascorbic acid in concentrated orange juice by the Ministry of Food, report on the fragmentation of scientific research by Sir Albert Howard, and notes on poultry farming, the supply of blood for manufacture of black pudding, and the extraction of cholesterol from pig's brain. Further to this there are three copies of 1 March 1943 edition of Food Manufacture, one copy of 5 September 1942 edition of The Veterinary Record opened to an article on 'The utilisation of Rumen Contents as Animal Fodder', and schools in war-time memorandum no. 34 produced by the Board of Education entitled 'War-Time Diet in Boarding Schools'.


Ministry of Supply - Toxic Workers (1942-1946)

Reference GB 133 JFW/2/5/4
Physical Description 22 items

Scope and Content

In January 1942 it was proposed that Wilkinson would carry out research under the title of "A Haematological Study of Mustard Gas Factory Workers" on behalf of the Ministry of Supply. The subjects were workers at Springfield, Sutton Oak, Randle, and Gaskell Marsh factories with non-toxic workers at several Ministry of Supply factories and Pilkington's Glass Works used as control samples. The research was to last for 6 months, but in the end investigations were continued up to 1946. The work was classified as secret with regular reports sent to the Deputy Controller General of Research and Development at the Ministry of Supply and any expenses claimed and requests to publish to go through the Controller of Chemical Defence Development at the Ministry of Supply. The workers concerned were employed in the mustard (toxic process), arsenical smoke (D.M.), and ethylene chlorhydrin plants.

Arrangement

  • JFW/2/5/4/1 - Administration
  • JFW/2/5/4/2 - Data Collection
  • JFW/2/5/4/3 - Investigation Reports
  • JFW/2/5/4/4 - Associated Mustard Gas Files

Administration (1942-1946)

Reference GB 133 JFW/2/5/4/1
Physical Description 3 items

Ministry of Supply Expenses, Receipts, Etc. ( 1942-1946)

Reference GB 133 JFW/2/5/4/1/1
Physical Description 1 file

Scope and Content

The file mainly consists of correspondence surrounding and details of expense claims made by Wilkinson against the Ministry of Supply for expenses incurred in the course of the investigations. The file also includes the notification sent to Wilkinson of the start of the investigation and its parameters as well as later correspondence extending the investigation for a longer period of time.


Ministry of Supply General Expenses (1943-1945)

Reference GB 133 JFW/2/5/4/1/2
Physical Description 1 volume

Scope and Content

Small notebook recording Wilkinson's general expenditure in the course of his investigations into toxic gas workers.


Correspondence (1942-1946)

Reference GB 133 JFW/2/5/4/1/3
Physical Description 1 file

Scope and Content

Five items of correspondence from July/August 1942 regarding gaining the cooperation of Pilkington Brothers Glass Works to allow their workers to be used as a control sample.

One letter received from Dr A. McLaren Ferrie in August 1946 regarding a potential visit to Sutton Oak.


Data Collection (1941-1945)

Reference GB 133 JFW/2/5/4/2
Physical Description 12 items

Scope and Content

Blood counts and reports of workers.


Springfield Initial Counts (1942)

Reference GB 133 JFW/2/5/4/2/1
Physical Description 1 file

Scope and Content

Initial or control blood counts taken for workers at Springfield at the beginning of the research in 1942, with categories of workers including: smoke 19; smoke 18; D.A. plant; red lead mixers; general electrical department; drains; plumbing department; instrument department; assembly; shift managers; plant managers; dressers and bathroom attendants; men; and women. There are also some repeat counts included from later in the year. Unlike the others Springfield was a new factory and so the initial control counts taken of workers there generally speaking were representative of their health prior to exposure.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Springfield Toxic Burns (1942)

Reference GB 133 JFW/2/5/4/2/2
Physical Description 1 file

Scope and Content

Comparative blood counts for workers at Springfield who have suffered toxic burns. A description of the burn is usually given with data from blood counts before and after the incident.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Springfield (1942-1944)

Reference GB 133 JFW/2/5/4/2/3
Physical Description 1 file

Scope and Content

Full blood counts for workers at Springfield subdivided into the following categories: toxic workers-males; toxic workers-females; J plant-males; J plant-females; assembly-males; assembly-females; miscellaneous non-toxic workers; non-toxic workers with counts affected; counts requested by the medical officer. There are two copies of each set of data.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Springfield (1943-1944)

Reference GB 133 JFW/2/5/4/2/4
Physical Description 1 file

Scope and Content

Blood counts of workers that are either anaemic or are working on 'P buildings' who have been marked for regular blood counts, either 2 monthly or 3 monthly.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Individual Springfield Blood Counts (1942-1946)

Reference GB 133 JFW/2/5/4/2/5
Physical Description 1 volume

Scope and Content

Volume of blood counts for workers at the Springfield factory divided into male and female non-toxic workers, toxic workers, smoke, general, and shipping. The latter half of the volume gives the initial counts taken for all workers, and in the front of the volume a single page is dedicated to each worker where all their blood counts are listed for the duration of the study therefore allowing for easy analysis of change.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Sutton Oak Initial Counts (1942-1943)

Reference GB 133 JFW/2/5/4/2/6
Physical Description 1 file

Scope and Content

Initial or control blood counts taken for workers at Sutton Oak at the beginning of the research in 1942, with categories of workers including: D.C. plant; D.M. plant; phenyl arsenic acid mixers for D.M.; lewisite plant; decontamination; destructor; laboratory staff; and fitters on process. There are further counts for workers on S plant from 1943, it is not clear if these are repeat counts or of a new plant was set up.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Sutton Oak (1942-1945)

Reference GB 133 JFW/2/5/4/2/7
Physical Description 1 file

Scope and Content

Full blood counts for workers at Sutton Oak subdivided into the following categories: process women; laboratory assistants-females; process men; laboratory staff-males; process fitters and fitter's mates; ambulance room; plumbers and mates; electricians; bricklayers; requests. There are two copies of each set of data.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Gaskell Marsh Initial Counts (13 July 1942)

Reference GB 133 JFW/2/5/4/2/8
Physical Description 1 file

Scope and Content

Initial or control blood counts taken for workers at Gaskell Marsh at the beginning of the research in 1942. 17 people were tested in total, 16 laboratory staff and 1 processman.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Gaskell Marsh (July 1942)

Reference GB 133 JFW/2/5/4/2/9
Physical Description 1 file

Scope and Content

Full blood counts for workers at Gaskell Marsh. There is only one set of data available for each worker but there are more workers included than there were in the first round of tests found in JFW/2/5/4/2/8, with additional workers having been tested later in the same month. Despite the datasets being headed 'males', female workers are included.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Randle (1941-1942)

Reference GB 133 JFW/2/5/4/2/10
Physical Description 1 file

Scope and Content

Full blood counts for workers at Randle. There are between 1 and 3 full blood counts from different dates recorded for each worker.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Valley (Nov 1941-Nov 1942)

Reference GB 133 JFW/2/5/4/2/11
Physical Description 1 file

Scope and Content

Blood counts for one worker at Valley comprising 23 counts taken over the course of the year.

Conditions Governing Access

This file lists individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Non-Toxic Workers (n.d. [194-])

Reference GB 133 JFW/2/5/4/2/12
Physical Description 1 file

Scope and Content

Full blood counts for non-toxic workers at Pilkington Brothers glass works and Ministry of Supply factories at Hillhouse, Rock Savage, and Wade, who acted as the control sample.

Conditions Governing Access

This file lists a number of individuals by name and gives personal medical information that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.


Investigation Reports (1942-1946)

Reference GB 133 JFW/2/5/4/3
Physical Description 4 items

Scope and Content

Reports compiled by various investigators at different stages of the investigation into the effects of toxic gas, some reporting on the general results and others focusing on specific factories or incidents.